CNRS Director of Research (DR CNRS, H.D.R.)
Dr. Angelina Angelova works at CNRS, the French largest public research organization. She has an H.D.R. degree (Habilitation à Diriger les Recherches) from the Université de Paris-Sud 11 (France) and an academic background in physical chemistry of self-assembled biomolecular nanostructures and biophysics of lipid membranes. Since 2005, Dr. Angelova has developed her expertise in lipid-based systems for drug nanoformulation, biomimetic self-assembly, and lipid nanoparticles (cubosomes, spongosomes, hexosomes, and vesicles) for therapeutic innovation and nanomedicine applications. Dr. Angelova has performed original research on the design and structural analysis of liquid crystalline nanocarriers of peptides, proteins, nucleic acids, and small bioactives. She is interested in the structural dynamics of lipid self-assembled nanoarchitectures, phase behavior of self-assembled biomolecular systems, lyotropic lipid polymorphism, physical chemistry and structural transitions of multicomponent membranes, cubic lipid membranes as protein nanoconfinement media, and membrane protein receptor organization and targeting. Dr. Angelova is a member of the Executive Council of the International Plasmalogen Society (IPLS) and a member of the Scientific Council of the research network GDR BIOMIM 2088 CNRS “Biomimetics and Bioinspiration”.
Recent publications:
- Wu, Y.; Wang, J.; Deng, Y.; Angelov, B.; Fujino, T.; Hossain, M.S.; Angelova, A. Lipid and Transcriptional Regulation in a Parkinson’s Disease Mouse Model by Intranasal Vesicular and Hexosomal Plasmalogen-based Nanomedicines. Adv. Healthcare Mater. 2024, 2304588. https://doi.org/10.1002/adhm.202304588
- Wu, Y.; Angelov, B.; Deng, Y.; Fujino, T.; Hossain, M.S.; Drechsler, M.; Angelova, A. Sustained CREB phosphorylation by lipid-peptide liquid crystalline nanoassemblies. Communications Chemistry. 2023, 6, 241. https://doi.org/10.1038/s42004-023-01043-9
- Yu, H.; Angelova, A.; Angelov, B.; Dyett, B.; Matthews, L.; Zhang, Y.; El Mohamad, M.; Cai, X.; Valimehr, S.; Drummond, C.J.; Zhai, J. Real-Time pH-Dependent Self-Assembly of Ionisable Lipids from COVID-19 Vaccines. Angew. Chem. Int. Ed. 2023, 62, e202304977. https://doi.org/10.1002/anie.202304977
- Wu, Y.; Angelova, A. Recent Uses of Lipid Nanoparticles, Cell-Penetrating and Bioactive Peptides for the Development of Brain-Targeted Nanomedicines against Neurodegenerative Disorders. Nanomaterials. 2023, 13, 3004. https://doi.org/10.3390/nano13233004.
- Akanchise, T.; Angelova, A. Potential of Nano-Antioxidants and Nanomedicine for Recovery from Neurological Disorders Linked to Long COVID Syndrome. Antioxidants 2023, 12, 393. https://doi.org/10.3390/antiox12020393
- Baranova, I.; Angelova, A.; Shepard, W.E.; Andreasson, J.; Angelov, B. Ice crystallization under cryogenic cooling in lipid membrane nanoconfined geometry: Time-resolved structural dynamics. J. Colloid Interface Sci. 2023, 634, 757-768. https://doi.org/10.1016/j.jcis.2022.12.095.
- Pimenta, B.V.; Madrid, R.R.M.; Mathews, P.D.; Riske, K.A.; Loh, W.; Angelov, B., Angelova, A.; Mertins, O. Interaction of polyelectrolyte-shell cubosomes with serum albumin for triggering drug release in gastrointestinal cancer. J. Mater. Chem. B, 2023, 11, 2490-2503. https://doi.org/10.1039/d2tb02670h
- Mathews, P.D.; Mertins, O.; Angelov, B.; Angelova, A. Cubosomal lipid nanoassemblies with pH-sensitive shells created by biopolymer complexes: A synchrotron SAXS study. J. Colloid Interface Sci. 2022, 607, 440-451. https://doi.org/10.1016/j.jcis.2021.08.
- Rakotoarisoa, M.; Angelov, B.; Drechsler, M.; Nicolas, V.; Bizien, T.; Gorshkova, Y.E.; Deng, Y.; Angelova, A. Liquid crystalline lipid nanoparticles for combined delivery of curcumin, fish oil and BDNF: In vitro neuroprotective potential in a cellular model of tunicamycin-induced endoplasmic reticulum stress. Smart Materials in Medicine. 2022, 3, 274–288. https://doi.org/10.1016/j.smaim.2022.03.001.
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